There are references to this ancient temple, since the reign of D. Fernando, when it served as the parish of São Tiago. At the time of Filipe I (1590) it underwent renovations that definitively changed its medieval appearance and in 1624, due to its state of neglect, it was rebuilt according to the taste of the time.

In 1932 its facade was completely renovated in the style of the late Italian Renaissance
Inside, the tiles, images and paintings came from the church and convent of Mónicas in Lisbon.
Noteworthy is the altar dedicated to Saint Sesinando and a relic of this saint, natural and patron of Beja, martyred in Córdoba on July 16, 851.